Chlorambucil plus CD20-Antikörper
نویسندگان
چکیده
منابع مشابه
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions.
BACKGROUND The monoclonal anti-CD20 antibody rituximab, combined with chemotherapeutic agents, has been shown to prolong overall survival in physically fit patients with previously untreated chronic lymphocytic leukemia (CLL) but not in those with coexisting conditions. We investigated the benefit of the type 2, glycoengineered antibody obinutuzumab (also known as GA101) as compared with that o...
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To assess whether chlorambucil or cyclophosphamide may have a better therapeutic index in patients with idiopathic membranous nephropathy, we compared two regimens based on a 6-mo treatment, alternating every other month methylprednisolone with chlorambucil or methylprednisolone with cyclophosphamide. Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomiz...
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Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse effects on patients. In this contribution, we propose a novel therapeutic approach in which relatively high doses of Hydroxychloroquine and Chlo...
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Table 1. Drug Acquisition, Administration, and Monitoring Costs for FirstLine Treatment With OChl and Chl Cost Type OChl Chl Drug acquisition Ofatumumab, 100 mg vial $336 – Chlorambucil, 25 x 2 mg pack $35 $35 Administration Induction infusion in first cycle (O) $1,039 – Regular infusion in subsequent cycles (O) $818 – Oral chemotherapy dispensing (Chl)a $9 $9 Monitoring (per chemo cycle)b $119...
متن کاملACP Journal Club. Prednisolone plus chlorambucil preserved renal function in membranous nephropathy.
Patients: 108 patients 18 to 75 years of age (mean age 57 y) with biopsy-proven IMN, serum or plasma creatinine level < 300 μmol/L, and ≥ 20% decline in excretory renal function based on ≥ 3 measurements over ≥ 3 months in the past 2 years. Exclusion criteria included infection with hepatitis B or C virus or HIV; malignancy; positive antibodies to double-stranded DNA; treatment with gold, penic...
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ژورنال
عنوان ژورنال: Info Onkologie
سال: 2013
ISSN: 1613-3633
DOI: 10.1007/s15004-013-0584-1